Fatty acid oxidation (FAO) metabolic switch: metastasis in lymph nodes driven by yes-associated protein (YAP) activation

The Hippo signaling pathway, which was first discovered in Drosophila, guides organ growth in many multicellular organisms by regulating the proliferation, differentiation, and death of cells (1,2). Because this pathway offers potential targets for anticancer agents, it is of great interest in biomedical research. The key effectors of the mammalian Hippo pathway are the yes-associated protein (YAP) of proto-oncogenes and its paralog, transcriptional coactivator with PDZ-binding motif (TAZ).