TY  - JOUR
AU  - Noma, Daisuke
AU  - Inamura, Kentaro
AU  - Matsuura, Yosuke
AU  - Ninomiya, Hironori
AU  - Ichinose, Junji
AU  - Nakao, Masayuki
AU  - Mun, Mingyon
AU  - Ishikawa, Yuichi
AU  - Okumura, Sakae
PY  - 2017
TI  - ALK-rearranged lung adenocarcinoma showing intra-bronchial protrusion: a case of actually peripheral origin with a rare spreading pattern
JF  - Biotarget; Vol 1 (November 2017): Biotarget
Y2  - 2017
KW  - 
N2  - We present a case of anaplastic lymphoma kinase (ALK)-rearranged lung adenocarcinoma, which showed intra-bronchial protrusion, but was found to be immunohistochemically positive for thyroid transcription factor-1 (TTF-1). To the best of our knowledge, this is the first case of ALK-rearranged lung cancer that presented as an elevated lesion projecting into the bronchial lumen. Although the tumor was located to be close the hilar region of the lung, it showed a positive immunohistochemical expression of TTF-1, which implied the peripheral origin of the tumor. This case highlights the need to consider the possibility of an ALK-rearranged lung adenocarcinoma of peripheral origin masquerading as a central-type tumor.
UR  - https://biotarget.amegroups.org/article/view/3881