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ALK-rearranged lung adenocarcinoma showing intra-bronchial protrusion: a case of actually peripheral origin with a rare spreading pattern

   
@article{Biotarget3881,
	author = {Daisuke Noma and Kentaro Inamura and Yosuke Matsuura and Hironori Ninomiya and Junji Ichinose and Masayuki Nakao and Mingyon Mun and Yuichi Ishikawa and Sakae Okumura},
	title = {ALK-rearranged lung adenocarcinoma showing intra-bronchial protrusion: a case of actually peripheral origin with a rare spreading pattern},
	journal = {Biotarget},
	volume = {1},
	number = {7},
	year = {2017},
	keywords = {},
	abstract = {We present a case of anaplastic lymphoma kinase (ALK)-rearranged lung adenocarcinoma, which showed intra-bronchial protrusion, but was found to be immunohistochemically positive for thyroid transcription factor-1 (TTF-1). To the best of our knowledge, this is the first case of ALK-rearranged lung cancer that presented as an elevated lesion projecting into the bronchial lumen. Although the tumor was located to be close the hilar region of the lung, it showed a positive immunohistochemical expression of TTF-1, which implied the peripheral origin of the tumor. This case highlights the need to consider the possibility of an ALK-rearranged lung adenocarcinoma of peripheral origin masquerading as a central-type tumor.},
	issn = {2522-669X},	url = {https://biotarget.amegroups.org/article/view/3881}
}