TY  - JOUR
AU  - Navari, Rudolph M.
PY  - 2017
TI  - Overview of the neurokinin-1 receptor antagonists
JF  - Biotarget; Vol 1 (July 2017): Biotarget
Y2  - 2017
KW  - 
N2  - Neurokinin-1 (NK-1) receptor antagonists block substance P-mediated NK-1 receptors which are present in the abdominal vagus, the brainstem, and the area postrema in the brainstem. Substance P is a mammalian tachykinin that is found in vagal afferent neurons innervating the brainstem and sends impulses to the vomiting center (1). Compounds that block NK-1 receptors lessen emesis after cisplatin, ipecac, apomorphine, and radiation therapy (1).
UR  - https://biotarget.amegroups.org/article/view/3703